Kombiglyze XR 500/5, delayed-release tablets, reduces blood sugar levels and protects against diabetic complications - 30 tablets
Scientific name
Saxagliptin 5 mg + Metformin 500 mg Tablets
Combiglyze XR 500/5 tablets belongs to
oral diabetes medications
How saxagliptin and metformin work
Saxagliptin is an inhibitor of DPP-4, an enzyme that breaks down incretin hormones, including glucagon-like peptide-1 (GLP-1).
Incretin helps the body produce more insulin only when it is needed and reduces the amount of glucose produced by the liver.
Metformin reduces blood glucose levels by decreasing glucose production in the liver.
Metformin reduces intestinal absorption of glucose.
Metformin increases insulin sensitivity, leading to increased glucose uptake and utilization.
Medical uses of Combiglyze XR 500/5 tablets
This medicine is used to treat a type of diabetes called type 2 diabetes.
Saxagliptin and metformin work together to control blood sugar.
It increases insulin levels after eating. It also reduces the amount of sugar your body produces in your liver.
Along with diet and exercise, this medication helps lower blood sugar.
This medication may be used alone or with other antidiabetic medications, including insulin.
How to use Combiglyze XR 500/5 tablets
Always take this medicine exactly as your doctor has told you. Consult your doctor or pharmacist if you are not sure.
If your doctor prescribes this medication with a sulfonylurea or insulin, remember to take this other medication as directed by your doctor to achieve the best results for your health.
The amount of this medicine you will take will vary depending on your condition.
Your doctor will tell you exactly how much of this medicine to take.
The recommended dosage is one tablet twice a day.
If you have impaired kidney function, your doctor may prescribe a lower dose.
Take this medicine by mouth.
Take it with a meal to reduce your chance of stomach upset (a side effect of the medication).
Doses may be changed under special circumstances, so always follow your doctor or pharmacist's instructions.
If you take more medicine than you should, talk to a doctor or go to the hospital immediately.
If you forget to take a dose, take it as soon as you remember unless it is almost time for your next dose.
Do not take a double dose (two doses at the same time) to make up for a missed dose.
Side effects of Combiglyze XR 500/5 tablets
Although the following side effects are not common to everyone, some patients may experience:
headache
muscle pain
indigestion
urinary tract infection
bronchitis
Inflammation of the nose or throat, such as a cold or sore throat
Inflammation of the stomach or digestive tract, sometimes caused by infection
Sinusitis, sometimes with pain and fullness behind the cheeks and eyes (sinusitis)
swelling
dizziness
fatigue
Use of Combiglyze XR 500/5 tablets during pregnancy and breastfeeding
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Your doctor will discuss the potential risks and benefits of using this medication during pregnancy and breastfeeding.
Helpful tips for diabetics
All carbohydrates affect blood glucose levels, so it's important to know which foods contain carbohydrates. Choose healthy carbohydrate-containing foods and be aware of the portion size (amount of carbohydrates) required.
Reduce your salt intake. Eating too much salt can increase your risk of high blood pressure, which in turn increases your risk of heart disease and stroke. When you have diabetes, you're already at greater risk for all of these conditions.
Eat more fruits and vegetables. This can help you get the vitamins, minerals, and fiber your body needs daily to maintain your health.
If you experience symptoms of hypoglycemia such as weakness, dizziness, increased sweating, rapid heartbeat, blurred vision, or difficulty concentrating, eating or drinking something containing sugar usually helps.
Warnings and precautions while using Combiglyze XR 500/5 tablets
Talk to your doctor or pharmacist before taking this medicine:
If you have type 1 diabetes
If you have or have had pancreatic disease
If you are taking insulin or an antidiabetic medicine known as a sulfonylurea
If you are allergic to any other medications you take to control your blood sugar
If you have a problem or take a medication that can lower your body's defense against infection
If you have ever had heart failure or have other risk factors for heart failure such as kidney problems
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including non-prescription medicines, prescription medicines, herbal supplements, vitamins, and nutritional supplements.
How to store Combiglyze XR 500/5 tablets
Store below 25°C.
Do not refrigerate the medicine.
Keep this medicine out of the sight and reach of children.
Must be stored in the original container to protect from moisture.
Do not use this medicine after the expiry date printed on the carton/blister/label. The expiry date refers to the last day of that month.
Your health in numbers
Random blood sugar test: A blood sample will be taken at a random time. Regardless of when you last ate, a blood sugar level of 200 milligrams per deciliter (mg/dL) or higher indicates diabetes. A blood sugar level below 140 mg/dL is considered normal, and a reading between 140 and 199 mg/dL indicates diabetes risk.
Fasting blood sugar test. A blood sample will be taken after you fast overnight. A fasting blood sugar level below 100 mg/dL is normal. A fasting blood sugar level of 100 to 125 mg/dL is considered prediabetes. If the level is 126 mg/dL or higher on two separate tests, you may have diabetes.
Oral glucose tolerance test: For this test, you fast overnight, and your fasting blood sugar level is measured. You then drink a sugary liquid, and your blood sugar levels are tested periodically for the next two hours.
For more information about saxagliptin and metformin
Consult your doctor or pharmacist.
Through the Saudi Food and Drug Authority's Tamenni app